A Prospective Study of the Impact of Low High-density Lipoprotein-cholesterol Level on 2-year Clinical Outcomes after Acute Myocardial Infarction in Patients with Diabetes Mellitus Original Research Paper

A total of 200 AMI patients with diabetes mellitus at RIMS,RAIPUR were divided into two groups based on HDL-C level on admission: normal HDL-C group (HDL-C ≥ 40 mg/dL, n = 100) and low HDL-C group (HDL-C < 40 mg/dL, n = 100). e primary endpoint was 2-year major adverse cardiovascular events (MACE), defined as a composite of cardiac death, non-fatal myocardial infarction (MI), and target vessel revascularization (TVR).In patients with diabetes mellitus, low HDL-C remained an independent risk predictor for MACE after adjusting for multiple risk factors during 2-year follow-up of AMI.Our main findings of the present study are as follows: (1) 46.2% of diabetic patients presenting with AMI had a low HDL-C level; (2) 2-year clinical outcomes including MACE (mainly cardiac death and TVR) were poorer in diabetic patients with a low HDL-C level after AMI compared to those with a normal HDL-C level; (3) low HDL-C level remained an important risk predictor for MACE after adjusting for confounding clinicalfactors.